John David Baker took over for Mitchell Gale at quarterback at the start of the final quarter. Gale's night ended after completing 19 of 28 passes for 290 yards and 1 TD.
ACU's string of seven straight scoring drives ended on its first drive of the quarter.
The Wildcats got the ball back when defensive back Angel Lopez intercepted a Jake McMullin pass at the McMurry 49 and returned it to the 35 with 10:39 remaining.
Marcel Threat scored his second TD of the night when he ran 12 yards to the end zone. Lineberry's sixth PAT of the night put ACU up 51-0 with 8:44 left.